Developer Mark Llobrera over at A List Apart gives advice for successfully integrating new web design and development techniques on new projects:
Look at the projects you have on the horizon. Think about the portions of your workflow that you want to improve, and pick just one of those things to introduce into your project. Why just one? It allows you enough space to experiment without endangering your project.
A mentor of mine once told me that programming (and especially programming for the web) boils down to reducing the number of “unknowns” on a project to a manageable number. One is fine, two is a stretch, and three is asking for trouble. If you think exploring HTML/CSS wireframes could have a positive impact on your work, introduce just that one thing. Most projects have enough built-in friction without adding or changing multiple processes at the same time.